Foundation Pharmacist Recruitment Practice Test 2025 – Your All-in-One Guide to Mastering the Exam!

Question: 1 / 400

What is the mechanism of action (MOA) of tamsulosin?

Beta-adrenergic blocker

Alpha-1 adreno receptor blocker

Tamsulosin functions primarily as an alpha-1 adrenoceptor blocker, targeting specifically the alpha-1A subtype of adrenergic receptors predominantly found in the prostate and bladder neck. By inhibiting these receptors, tamsulosin facilitates relaxation of the smooth muscle in the bladder neck and prostate, leading to improved urinary flow and reduction in symptoms associated with benign prostatic hyperplasia (BPH). This mechanism is critical for alleviating urinary difficulties in men with BPH, as it directly addresses the obstruction caused by enlarged prostate tissue.

The other options do not accurately represent the mechanism of action for tamsulosin. Beta-adrenergic blockers primarily affect heart rate and blood pressure but do not have the same targeted effects on the prostate and urinary tract. Calcium channel blockers are used for different indications, such as hypertension and certain types of cardiac arrhythmias, and do not have a direct role in relieving urinary symptoms associated with BPH. Direct vasodilators work by relaxing blood vessels to lower blood pressure but do not specifically target the smooth muscle of the urinary tract. Hence, the correct understanding of tamsulosin’s mechanism of action is crucial for its appropriate use in managing urinary symptoms in affected patients.

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Calcium channel blocker

Direct vasodilator

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